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β1 INTEGRIN IS CRITICAL FOR THE MAINTENANCE OF ANTIGEN-SPECIFIC CD4 T CELLS IN THE BONE MARROW BUT NOT LONG-TERM IMMUNOLOGICAL MEMORY

The long-term maintenance of memory CD4 T cells promotes protective immunity against future pathogen re-infection. As a site rich in survival cytokines, the bone marrow is proposed to be a critical niche for the survival of memory CD4 T cells. We demonstrate that endogenous, polyclonal Ag-specific C...

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Autors principals: DeNucci, Christopher C., Shimizu, Yoji
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062718/
https://ncbi.nlm.nih.gov/pubmed/21357540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003566
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