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BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas
BCAR3 binds to the carboxy-terminus of p130Cas, a focal adhesion adapter protein. Both BCAR3 and p130Cas have been linked to resistance to anti-estrogens in breast cancer, Rac activation and cell motility. Using R743A BCAR3, a point mutant that has lost the ability to bind p130Cas, we find that BCAR...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062698/ https://ncbi.nlm.nih.gov/pubmed/21262352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.01.018 |
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