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Depletion of the Bloom Syndrome Helicase Stimulates Homology-Dependent Repair at Double-Strand Breaks in Human Chromosomes

Mutation of BLM helicase causes Blooms syndrome, a disorder associated with genome instability, high levels of sister chromatid exchanges, and cancer predisposition. To study the influence of BLM on double-strand break (DSB) repair in human chromosomes, we stably transfected a normal human cell line...

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Detalhes bibliográficos
Main Authors: Wang, Yibin, Smith, Krissy, Waldman, Barbara Criscuolo, Waldman, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062690/
https://ncbi.nlm.nih.gov/pubmed/21300576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2011.01.009
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