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Cholesterol 5,6-secosterol Aldehyde Adduction to Membrane-Bound Myelin Basic Protein Exposes an Immunodominant Epitope
Myelin degradation in the CNS is a clinical hallmark of multiple sclerosis (MS). A reduction in the net positive charge of myelin basic protein (MBP) via deimination of arginine to citrulline, has been shown to correlate strongly with disease severity and has been linked to myelin instability and a...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062686/ https://ncbi.nlm.nih.gov/pubmed/21314187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200109q |
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