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Mad2 Haploinsufficiency Protects Hematopoietic Progenitor Cells Subjected to Cell Cycle Stress In Vivo and to Inhibition of Redox Function of Ape1/Ref-1 In Vitro

OBJECTIVE: Cell cycle checkpoints guarantee movement through the cell cycle. Mitotic arrest deficiency 2 (Mad2), a mitotic checkpoint protein, appears crucial for generating the wait anaphase signal to prevent onset of anaphase. We evaluated effects of Mad2 haploinsufficiency on hematopoietic stem (...

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Bibliografski detalji
Glavni autori: Rohrabaugh, Sara L., Hangoc, Giao, Kelley, Mark R., Broxmeyer, Hal E.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062656/
https://ncbi.nlm.nih.gov/pubmed/21216274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2010.12.012
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