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C(20)-trifluoro-5-oxo-ETE: A metabolically stable 5-oxo-ETE derivative
The total synthesis of C(20)-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation-resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062511/ https://ncbi.nlm.nih.gov/pubmed/21377873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.02.021 |
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