Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein

Resistance to apoptosis is a hallmark of many solid tumors, including pancreatic cancers, and may be the underlying basis for the suboptimal response to chemo-radiation therapies. Overexpression of a family of inhibitor of apoptosis proteins (IAP) is commonly observed in pancreatic malignancies. We...

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Detalhes bibliográficos
Main Authors: Karikari, Collins A., Roy, Indrajit, Tryggestad, Eric, Feldmann, Georg, Pinilla, Clemencia, Welsh, Kate, Reed, John C., Armour, Elwood P., Wong, John, Herman, Joseph, Rakheja, Dinesh, Maitra, Anirban
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062431/
https://ncbi.nlm.nih.gov/pubmed/17339366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-06-0634
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