MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation

Actin filament remodeling regulates several endothelial cell (EC) processes such as contraction, migration, adhesion, and shape determination. Mitogen-activated protein kinase (MAPK)–activated protein kinase 2 (MK2)–mediated phosphorylation of heat-shock protein 27 kDa (HSP27) promotes actin filamen...

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Detalhes bibliográficos
Main Authors: Chang, Eugene, Heo, Kyung-Sun, Woo, Chang-Hoon, Lee, Hakjoo, Le, Nhat-Tu, Thomas, Tamlyn N., Fujiwara, Keigi, Abe, Jun-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062414/
https://ncbi.nlm.nih.gov/pubmed/21131586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-302281
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