Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis

Somatic gain-of-function mutations in members of the RAS subfamily of small guanosine triphosphatases are found in > 30% of all human cancers. We recently described a syndrome of chronic nonmalignant lymphadenopathy, splenomegaly, and autoimmunity associated with a mutation in NRAS affecting hema...

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Autors principals: Niemela, Julie E., Lu, Lianghao, Fleisher, Thomas A., Davis, Joie, Caminha, Iusta, Natter, Marc, Beer, Laurel A., Dowdell, Kennichi C., Pittaluga, Stefania, Raffeld, Mark, Rao, V. Koneti, Oliveira, João B.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062298/
https://ncbi.nlm.nih.gov/pubmed/21079152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-295501
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