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Structural integrity of α-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability

Translation initiation factor eIF5B promotes GTP-dependent ribosomal subunit joining in the final step of the translation initiation pathway. The protein resembles a chalice with the α-helix H12 forming the stem connecting the GTP-binding domain cup to the domain IV base. Helix H12 has been proposed...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shin, Byung-Sik, Acker, Michael G., Kim, Joo-Ran, Maher, Kathryn N., Arefin, Shamsul M., Lorsch, Jon R., Dever, Thomas E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062179/
https://ncbi.nlm.nih.gov/pubmed/21335519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2412511
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