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Structural integrity of α-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability
Translation initiation factor eIF5B promotes GTP-dependent ribosomal subunit joining in the final step of the translation initiation pathway. The protein resembles a chalice with the α-helix H12 forming the stem connecting the GTP-binding domain cup to the domain IV base. Helix H12 has been proposed...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062179/ https://ncbi.nlm.nih.gov/pubmed/21335519 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2412511 |
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