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Colonic inflammation alters Src kinase-dependent gating properties of single Ca(2+) channels via tyrosine nitration

Nitration of L-type calcium channels during colonic inflammation impairs phosphorylation by the tyrosine kinase, Src kinase. This results in decreased calcium currents. The purpose of this study was to determine the mechanism of the downregulation of Ca(2+) currents in colonic inflammation. In whole...

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Main Authors: Ross, Gracious R., Kang, Minho, Akbarali, Hamid I.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061627/
https://ncbi.nlm.nih.gov/pubmed/20378833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00056.2010
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