The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): Characterization of the In Vitro Profile and In Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward

Certain behavioral features of buprenorphine, including a bell-shaped curve for antinociception and attenuation of alcohol consumption, are thought to be mediated by activation of nociceptin/orphanin FQ peptide (NOP) receptors, despite moderate affinity and low efficacy at NOP receptors. We hypothes...

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Main Authors: Khroyan, Taline V., Polgar, Willma E., Cami-Kobeci, Gerta, Husbands, Stephen M., Zaveri, Nurulain T., Toll, Lawrence
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2011
主題:
Neuropharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061529/
https://ncbi.nlm.nih.gov/pubmed/21177476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175620
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