Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening

We screened 124 genes that are amplified in human HCC using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19. Although it is widely assumed that CCND1 is the main driving oncogene of this common amplicon (15% frequency in HCC), bot...

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Detalhes bibliográficos
Main Authors: Sawey, Eric T., Chanrion, Maia, Cai, Chunlin, Wu, Guanming, Zhang, Jianping, Zender, Lars, Zhao, Alice, Busuttil, Ronald W., Yee, Herman, Stein, Lincoln, French, Dorothy M., Finn, Richard S., Lowe, Scott W., Powers, Scott
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061399/
https://ncbi.nlm.nih.gov/pubmed/21397858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.01.040
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