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DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators.
The DNA unwinding effects of some 9-aminoacridine derivatives were compared under reaction conditions that could be used to study drug-induced topoisomerase II inhibition. An assay was designed to determine drug-induced DNA unwinding by using L1210 topoisomerase I. 9-aminoacridines could be ranked b...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
1987
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC306134/ https://ncbi.nlm.nih.gov/pubmed/2819825 |
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