Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit

NpmA, a methyltransferase that confers resistance to aminoglycosides was identified in an Escherichia coli clinical isolate. It belongs to the kanamycin–apramycin methyltransferase (Kam) family and specifically methylates the 16S rRNA at the N1 position of A1408. We determined the structures of apo-...

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Hlavní autoři: Husain, Nilofer, Obranić, Sonja, Koscinski, Lukasz, Seetharaman, J., Babić, Fedora, Bujnicki, Janusz M., Maravić-Vlahoviček, Gordana, Sivaraman, J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061052/
https://ncbi.nlm.nih.gov/pubmed/21062819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1033
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