Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m(7)G methyltransferases

Sgm (Sisomicin-gentamicin methyltransferase) from antibiotic-producing bacterium Micromonospora zionensis is an enzyme that confers resistance to aminoglycosides like gentamicin and sisomicin by specifically methylating G1405 in bacterial 16S rRNA. Sgm belongs to the aminoglycoside resistance methyl...

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Detalhes bibliográficos
Main Authors: Husain, Nilofer, Tkaczuk, Karolina L., Tulsidas, Shenoy Rajesh, Kaminska, Katarzyna H., Čubrilo, Sonja, Maravić-Vlahoviček, Gordana, Bujnicki, Janusz M., Sivaraman, J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2896518/
https://ncbi.nlm.nih.gov/pubmed/20194115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq122
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