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Ubiquitin Proteasomal Pathway Mediated Degradation of p53 in Melanoma
Ubiquitin proteasomal pathway (UPP) is the principle mechanism for protein catabolism and affects cellular processes critical for survival and proliferation. Levels of tumor suppressor protein p53 are very low in cells due to its rapid turnover by UPP-mediated degradation. While p53 is mutated in hu...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3060965/ https://ncbi.nlm.nih.gov/pubmed/21167122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2010.12.012 |
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