The Relationship between the Val158Met Catechol-o-Methyltransferase (COMT) Polymorphism and Irritable Bowel Syndrome

BACKGROUND: The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. The val/val genotype results in a three to fourfold higher enzymatic activity compared with the met/met genotype, with the val/met genotype e...

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Bibliographic Details
Main Authors: Karling, Pontus, Danielsson, Åke, Wikgren, Mikael, Söderström, Ingegerd, Del-Favero, Jurgen, Adolfsson, Rolf, Norrback, Karl-Fredrik
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060919/
https://ncbi.nlm.nih.gov/pubmed/21437260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018035
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