An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4(+) T Cell Responses in Seronegative Volunteers

Background. This phase I/II partially blinded, randomized, dose-ranging study assessed the safety and immunogenicity of a novel human immunodeficiency virus type 1 (HIV-1) vaccine candidate consisting of a recombinant fusion protein (F4) containing 4 HIV-1 clade B antigens (Gag p24, Pol reverse tran...

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Main Authors: Van Braeckel, Eva, Bourguignon, Patricia, Koutsoukos, Marguerite, Clement, Frédéric, Janssens, Michel, Carletti, Isabelle, Collard, Alix, Demoitié, Marie-Ange, Voss, Gerald, Leroux-Roels, Geert, McNally, Lisa
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
HIV/AIDS
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060898/
https://ncbi.nlm.nih.gov/pubmed/21208909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciq160
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