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Ultrasensitivity in the regulation of Cdc25C by Cdk1

Cdc25C is a critical component of the interlinked positive and double-negative feedback loops that constitute the bistable mitotic trigger. Computational studies have indicated that the trigger’s bistability should be more robust if the individual legs of the loops exhibit ultrasensitive responses....

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Autori principali: Trunnell, Nicole B., Poon, Andy C., Kim, Sun Young, Ferrell, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060667/
https://ncbi.nlm.nih.gov/pubmed/21292159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.01.012
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