Cooperativity within and between Pten, p53 and Rb pathways induces high-grade astrocytoma in adult brain

Mutations in the PTEN, TP53 and RB1 pathways are obligate events in the pathogenesis of human glioblastomas. We induced various combinations of deletions in these tumor suppressors in astrocytes and neural precursors in mature mice, resulting in astrocytomas ranging from grade III to grade IV (gliob...

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Main Authors: Chow, Lionel M.L., Endersby, Raelene, Zhu, Xiaoyan, Rankin, Sherri, Qu, Chunxu, Zhang, Junyuan, Broniscer, Alberto, Ellison, David W., Baker, Suzanne J.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060664/
https://ncbi.nlm.nih.gov/pubmed/21397855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.01.039
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