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Deep resequencing reveals excess rare recent variants consistent with explosive population growth

Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has been unfeasible until now. Here, we applied Sanger sequencing of genomic PCR amplicons to resequence the diabetes-associated genes KCNJ11 an...

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Bibliographische Detailangaben
Hauptverfasser: Coventry, Alex, Bull-Otterson, Lara M., Liu, Xiaoming, Clark, Andrew G., Maxwell, Taylor J., Crosby, Jacy, Hixson, James E., Rea, Thomas J., Muzny, Donna M., Lewis, Lora R., Wheeler, David A., Sabo, Aniko, Lusk, Christine, Weiss, Kenneth G., Akbar, Humeira, Cree, Andrew, Hawes, Alicia C., Newsham, Irene, Varghese, Robin T., Villasana, Donna, Gross, Shannon, Joshi, Vandita, Santibanez, Jireh, Morgan, Margaret, Chang, Kyle, IV, Walker Hale, Templeton, Alan R., Boerwinkle, Eric, Gibbs, Richard, Sing, Charles F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060603/
https://ncbi.nlm.nih.gov/pubmed/21119644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1130
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