Deep resequencing reveals excess rare recent variants consistent with explosive population growth

Accurately determining the distribution of rare variants is an important goal of human genetics, but resequencing of a sample large enough for this purpose has been unfeasible until now. Here, we applied Sanger sequencing of genomic PCR amplicons to resequence the diabetes-associated genes KCNJ11 an...

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में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Coventry, Alex, Bull-Otterson, Lara M., Liu, Xiaoming, Clark, Andrew G., Maxwell, Taylor J., Crosby, Jacy, Hixson, James E., Rea, Thomas J., Muzny, Donna M., Lewis, Lora R., Wheeler, David A., Sabo, Aniko, Lusk, Christine, Weiss, Kenneth G., Akbar, Humeira, Cree, Andrew, Hawes, Alicia C., Newsham, Irene, Varghese, Robin T., Villasana, Donna, Gross, Shannon, Joshi, Vandita, Santibanez, Jireh, Morgan, Margaret, Chang, Kyle, IV, Walker Hale, Templeton, Alan R., Boerwinkle, Eric, Gibbs, Richard, Sing, Charles F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2010
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060603/
https://ncbi.nlm.nih.gov/pubmed/21119644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1130
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