Resequencing of IRS2 reveals rare variants for obesity but not fasting glucose homeostasis in Hispanic children

Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5′ and 3′ flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymo...

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Autori principali: Butte, Nancy F., Voruganti, V. Saroja, Cole, Shelley A., Haack, Karin, Comuzzie, Anthony G., Muzny, Donna M., Wheeler, David A., Chang, Kyle, Hawes, Alicia, Gibbs, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2011
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Call for Papers: Functional Analysis of Sequence Variation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3180738/
https://ncbi.nlm.nih.gov/pubmed/21771880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00019.2011
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