Calpain-mediated Proteolysis of Paxillin Negatively Regulates Focal Adhesion Dynamics and Cell Migration

The dynamic turnover of integrin-mediated adhesions is important for cell migration. Paxillin is an adaptor protein that localizes to focal adhesions and has been implicated in cell motility. We previously reported that calpain-mediated proteolysis of talin1 and focal adhesion kinase mediates adhesi...

Full description

Saved in:
Bibliographic Details
Main Authors: Cortesio, Christa L., Boateng, Lindsy R., Piazza, Timothy M., Bennin, David A., Huttenlocher, Anna
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060554/
https://ncbi.nlm.nih.gov/pubmed/21270128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.187294
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items