Myocyte Enhancer Factor-2 Interacting Transcriptional Repressor (MITR) Is a Switch That Promotes Osteogenesis and Inhibits Adipogenesis of Mesenchymal Stem Cells by Inactivating Peroxisome Proliferator-activated Receptor γ-2

EZH2, a catalytic subunit of Polycomb-repressive complex 2 (PRC2), is a histone lysine methyltransferase that methylates lysine 27 of histone H3, resulting in gene silencing. It has been shown that EZH2 plays a pivotal role in fostering self-renewal and inhibiting the differentiation of embryonic st...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Ya-Huey, Yeh, Fang-Ling, Yeh, Su-Peng, Ma, Haou-Tzong, Hung, Shih-Chieh, Hung, Mien-Chie, Li, Long-Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060518/
https://ncbi.nlm.nih.gov/pubmed/21247904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199612
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