The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

Ribonuclease H2 (RNase H2) is the major nuclear enzyme involved in the degradation of RNA/DNA hybrids and removal of ribonucleotides misincorporated in genomic DNA. Mutations in each of the three RNase H2 subunits have been implicated in a human auto-inflammatory disorder, Aicardi-Goutières Syndrome...

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Main Authors: Reijns, Martin A. M., Bubeck, Doryen, Gibson, Lucien C. D., Graham, Stephen C., Baillie, George S., Jones, E. Yvonne, Jackson, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060506/
https://ncbi.nlm.nih.gov/pubmed/21177854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177394
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