Thrombin Induces NF-κB Activation and IL-8/CXCL8 Expression in Lung Epithelial Cells by a Rac1-dependent PI3K/Akt Pathway

We previously showed that thrombin induces interleukin (IL)-8/CXCL8 expression via the protein kinase C (PKC)α/c-Src-dependent IκB kinase α/β (IKKα/β)/NF-κB signaling pathway in human lung epithelial cells. In this study, we further investigated the roles of Rac1, phosphoinositide 3-kinase (PI3K), a...

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Main Authors: Lin, Chien-Huang, Cheng, Hui-Wen, Ma, Hon-Ping, Wu, Chih-Hsiung, Hong, Chuang-Ye, Chen, Bing-Chang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060502/
https://ncbi.nlm.nih.gov/pubmed/21266580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.112433
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