Vaccinia H1-related Phosphatase Is a Phosphatase of ErbB Receptors and Is Down-regulated in Non-small Cell Lung Cancer

Vaccinia H1-related phosphatase (VHR) is classified as a dual specificity phosphatase. Unlike typical dual specificity phosphatases, VHR lacks the MAPK-binding domain and shows poor activity against MAPKs. We found that EGF receptor (EGFR) was a direct substrate of VHR and that overexpression of VHR...

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Autors principals: Wang, Jiz-Yuh, Yeh, Chi-Ling, Chou, Hsiao-Chin, Yang, Chi-Hwa, Fu, Yu-Ning, Chen, Ya-Ting, Cheng, Hui-Wen, Huang, Chi-Ying F., Liu, Hui-Ping, Huang, Shiu-Feng, Chen, Yi-Rong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060470/
https://ncbi.nlm.nih.gov/pubmed/21262974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.163295
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