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Intrarenal Angiotensin-Converting Enzyme Induces Hypertension in Response to Angiotensin I Infusion

The contribution of the intrarenal renin-angiotensin system to the development of hypertension is incompletely understood. Here, we used targeted homologous recombination to generate mice that express angiotensin-converting enzyme (ACE) in the kidney tubules but not in other tissues. Mice homozygous...

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Detalles Bibliográficos
Main Authors: Gonzalez-Villalobos, Romer A., Billet, Sandrine, Kim, Catherine, Satou, Ryousuke, Fuchs, Sebastien, Bernstein, Kenneth E., Navar, L. Gabriel
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060439/
https://ncbi.nlm.nih.gov/pubmed/21115616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010060624
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