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Overturning Indolyne Regioselectivities and Synthesis of Indolactam V

We report the design and synthesis of an indolyne that displays a reversal in regioselectivity, in both nucleophilic addition and cycloaddition reactions, compared to typical 4,5-indolynes. Our approach utilizes simple computations to predict regioselectivity in reactions of unsymmetrical arynes. Wi...

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Main Authors: Bronner, Sarah M., Goetz, Adam E., Garg, Neil K.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060274/
https://ncbi.nlm.nih.gov/pubmed/21351773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200437g
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