The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

Mutations in the serine-threonine kinase (LKB1) lead to a gastrointestinal hamartomatous polyposis disorder with increased predisposition to cancer (Peutz–Jeghers syndrome). LKB1 has many targets, including the AMP-activated protein kinase (AMPK) that is phosphorylated under low-energy conditions. A...

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Bibliographic Details
Main Authors: van der Velden, Yme U., Wang, Liqin, Zevenhoven, John, van Rooijen, Ellen, van Lohuizen, Maarten, Giles, Rachel H., Clevers, Hans, Haramis, Anna-Pavlina G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060253/
https://ncbi.nlm.nih.gov/pubmed/21368212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010210108
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