Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

Somatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae diploid cells produce daughters without mitochondrial DNA, leading to loss of respiration competence and increased loss of heterozygosity (LOH)...

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Bibliographic Details
Main Authors: Lindstrom, Derek L., Leverich, Christina K., Henderson, Kiersten A., Gottschling, Daniel E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060066/
https://ncbi.nlm.nih.gov/pubmed/21436897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002015
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