Replicative Age Induces Mitotic Recombination in the Ribosomal RNA Gene Cluster of Saccharomyces cerevisiae

Somatic mutations contribute to the development of age-associated disease. In earlier work, we found that, at high frequency, aging Saccharomyces cerevisiae diploid cells produce daughters without mitochondrial DNA, leading to loss of respiration competence and increased loss of heterozygosity (LOH)...

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Main Authors: Lindstrom, Derek L., Leverich, Christina K., Henderson, Kiersten A., Gottschling, Daniel E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3060066/
https://ncbi.nlm.nih.gov/pubmed/21436897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002015
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