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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
Little is known about metabolic regulation in stem cells and how this modulates tissue regeneration or tumour suppression. We studied the Lkb1 tumour suppressor, and its substrate AMPK, kinases that coordinate metabolism with cell growth. Lkb1 deletion caused increased haematopoietic stem cell (HSC)...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059717/ https://ncbi.nlm.nih.gov/pubmed/21124450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09571 |
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