Comparing protein–ligand interactions in solution and single crystals by Raman spectroscopy

By using a Raman microscope, we show that it is possible to probe the conformational states in protein crystals and crystal fragments under growth conditions (in hanging drops). The flavin cofactor in the enzyme para-hydroxybenzoate hydroxylase can assume two conformations: buried in the protein mat...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Altose, Michael D., Zheng, Yuangang, Dong, Jian, Palfey, Bruce A., Carey, Paul R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11248022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061029598
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