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Co-directional replication-transcription conflicts lead to replication restart
Head-on encounters between the replication and transcription machineries on the lagging DNA strand can lead to replication fork arrest and genomic instability1,2. To avoid head-on encounters, most genes, especially essential and highly transcribed genes, are encoded on the leading strand such that t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3059490/ https://ncbi.nlm.nih.gov/pubmed/21350489 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09758 |
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