The Coxsackievirus B 3C(pro) Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

The host innate immune response to viral infections often involves the activation of parallel pattern recognition receptor (PRR) pathways that converge on the induction of type I interferons (IFNs). Several viruses have evolved sophisticated mechanisms to attenuate antiviral host signaling by direct...

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Detalhes bibliográficos
Main Authors: Mukherjee, Amitava, Morosky, Stefanie A., Delorme-Axford, Elizabeth, Dybdahl-Sissoko, Naomi, Oberste, M. Steven, Wang, Tianyi, Coyne, Carolyn B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059221/
https://ncbi.nlm.nih.gov/pubmed/21436888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001311
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