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Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation

Prion diseases occur following the conversion of the cellular prion protein (PrP(C)) into a disease related, protease-resistant isoform (PrP(Sc)). In these studies, a cell painting technique was used to introduce PrP(C) to prion-infected neuronal cell lines (ScGT1, ScN2a, or SMB cells). The addition...

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Bibliografiske detaljer
Main Authors: Bate, Clive, Williams, Alun
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059045/
https://ncbi.nlm.nih.gov/pubmed/21212283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186833
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