Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter

Haptoglobin (Hp) is known to play a role in angiogenesis as well as in anti-inflammation. STAT3 is a major transcription factor for expression of human Hp. We investigated whether hypoxia-inducible factor-1α (HIF-1α), a key mediator of angiogenesis, participates in Hp gene expression. HIF-1α overexp...

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Bibliographic Details
Main Authors: Oh, Mi-Kyung, Park, Hyo-Jung, Kim, Nam-Hoon, Park, Seon-Joo, Park, In-Yang, Kim, In-Sook
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058976/
https://ncbi.nlm.nih.gov/pubmed/21224490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150557
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