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Mucolipin-3 Regulates Luminal Calcium, Acidification, and Membrane Fusion in the Endosomal Pathway

Mucolipin-3 (MCOLN3) is a pH-regulated Ca(2+) channel that localizes to the endosomal pathway. Gain-of-function mutation in MCOLN3 causes the varitint-waddler (Va) phenotype in mice, which is characterized by hearing loss, vestibular dysfunction, and coat color dilution. The Va phenotype results fro...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lelouvier, Benjamin, Puertollano, Rosa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058973/
https://ncbi.nlm.nih.gov/pubmed/21245134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.169185
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