Expression of PD-L1 and PD-L2 on human macrophages is up-regulated by HIV-1 and differentially modulated by IL-10

PD-1 plays an important role in T cell exhaustion during HIV infection. PD-1 has two ligands: PD-L1, expressed on hematopoietic and nonhematopoietic cells, and PD-L2, limited to DCs and macrophages. Little is known about PD-L1 expression and regulation in human macrophages. Previous reports have fou...

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Main Authors: Rodríguez-García, Marta, Porichis, Filippos, de Jong, Olivier G., Levi, Karen, Diefenbach, Thomas J., Lifson, Jeffrey D., Freeman, Gordon J., Walker, Bruce D., Kaufmann, Daniel E., Kavanagh, Daniel G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2011
Assuntos:
Spotlight on Leading Edge Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058820/
https://ncbi.nlm.nih.gov/pubmed/21097698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0610327
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