LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum
Lhs1p is an Hsp70-related chaperone localized in the endoplasmic reticulum (ER) lumen. Δlhs1 mutant cells are viable but are constitutively induced for the unfolded protein response (UPR). Here, we demonstrate a severe growth defect in Δire1Δlhs1 double mutant cells in which the UPR can no longer be...
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| Pubblicato in: | EMBO J |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305876/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11101517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.23.6440 |
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