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LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum

Lhs1p is an Hsp70-related chaperone localized in the endoplasmic reticulum (ER) lumen. Δlhs1 mutant cells are viable but are constitutively induced for the unfolded protein response (UPR). Here, we demonstrate a severe growth defect in Δire1Δlhs1 double mutant cells in which the UPR can no longer be...

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Bibliografske podrobnosti
Main Authors: Tyson, John R., Stirling, Colin J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC305876/
https://ncbi.nlm.nih.gov/pubmed/11101517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.23.6440
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