Resveratrol blocks Akt activation in angiotensin II- or EGF-stimulated vascular smooth muscle cells in a redox-independent manner

AIMS: Resveratrol (RV), an antioxidant, inhibits angiotensin II (Ang II)-induced hypertrophy and Ang II- or epidermal growth factor (EGF)-induced Akt phosphorylation in rat vascular smooth muscle cells (VSMCs). Both signalling pathways are reported to utilize reactive oxygen species (ROS). The aim o...

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Main Authors: Schreiner, Cornelia E., Kumerz, Mario, Gesslbauer, Julia, Schachner, Daniel, Joa, Helge, Erker, Thomas, Atanasov, Atanas G., Heiss, Elke H., Dirsch, Verena M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058730/
https://ncbi.nlm.nih.gov/pubmed/21071431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvq355
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