p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

The stress-responsive p38 MAPK, when activated by genotoxic stresses such as UV radiation, enhances p53 activity by phosphorylation and leads to cell cycle arrest or apoptosis. Here we report that a member of the protein phosphatase type 2C family, Wip1, has a role in down-regulating p38-p53 signali...

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Hauptverfasser: Takekawa, Mutsuhiro, Adachi, Masaaki, Nakahata, Atsuko, Nakayama, Ichiro, Itoh, Fumio, Tsukuda, Hiroyuki, Taya, Yoichi, Imai, Kohzoh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2000
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305857/
https://ncbi.nlm.nih.gov/pubmed/11101524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.23.6517
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