Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations

OBJECTIVES: HIV-1 reverse transcriptase (RT) mutations associated with antiviral drug resistance have been extensively characterized in the enzyme polymerase domain. Recent studies, however, have verified the involvement of the RT C-terminal domains (connection and RNase H) in drug resistance to RT...

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Detalhes bibliográficos
Main Authors: Lengruber, Renan B., Delviks-Frankenberry, Krista A., Nikolenko, Galina N., Baumann, Jessica, Santos, André F., Pathak, Vinay K., Soares, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058567/
https://ncbi.nlm.nih.gov/pubmed/21393163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr005
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