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Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist

Dopamine modulates movement, cognitive, and emotional functions of the brain through activation of dopamine receptors that belong to the G protein-coupled receptor (GPCR) superfamily. Here we present the crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R...

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Autors principals: Chien, Ellen Y.T., Liu, Wei, Zhao, Qiang, Katritch, Vsevolod, Han, Gye Won, Hanson, Michael A., Shi, Lei, Newman, Amy Hauck, Javitch, Jonathan A., Cherezov, Vadim, Stevens, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058422/
https://ncbi.nlm.nih.gov/pubmed/21097933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1197410
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