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Orexin Receptors: Pharmacology and Therapeutic Opportunities

Orexin-A and -B (also known as hypocretin-1 and -2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 receptors. In fact, they are necessary for normal wakefulness, as loss of the orexin-producing neurons causes narcolepsy in humans a...

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Detalhes bibliográficos
Main Authors: Scammell, Thomas E., Winrow, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058259/
https://ncbi.nlm.nih.gov/pubmed/21034217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pharmtox-010510-100528
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