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Knockdown of Orexin Type I Receptor in Rat Locus Coeruleus increases REM Sleep during the Dark Period
The locus coeruleus (LC) regulates sleep/wakefulness and is densely innervated by orexinergic neurons in the lateral hypothalamus. Here we used small interfering RNAs (siRNAs) to test the role of LC orexin type 1 receptor (OxR1) in sleep-wake control. In sleep studies, bilateral Ox1R siRNA injection...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058252/ https://ncbi.nlm.nih.gov/pubmed/21089218 |
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