Retrochalcone derivatives are positive allosteric modulators at synaptic and extrasynaptic GABA(A) receptors in vitro

BACKGROUND AND PURPOSE: Flavonoids, important plant pigments, have been shown to allosterically modulate brain GABA(A) receptors (GABA(A)Rs). We previously reported that trans-6,4′-dimethoxyretrochalcone (Rc-OMe), a hydrolytic derivative of the corresponding flavylium salt, displayed nanomolar affin...

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Detalhes bibliográficos
Main Authors: Jiang, Ruotian, Miyamoto, Akiko, Martz, Adeline, Specht, Alexandre, Ishibashi, Hitoshi, Kueny-Stotz, Marie, Chassaing, Stefan, Brouillard, Raymond, de Carvalho, Lia Prado, Goeldner, Maurice, Nabekura, Junichi, Nielsen, Mogens, Grutter, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2011
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058165/
https://ncbi.nlm.nih.gov/pubmed/21133889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.01142.x
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